Disruptors in the PsO and PsA Market: Weighing Clearance, Convenience and Cost

By: Vania Galarraga, MPH, Engagement ManagerSkin diseases constitute one of the leading causes of health burden worldwide, measured as disability-adjusted life years (DALYs). Among skin diseases, psoriasis (PsO) carries the third-largest disability weight, which translates into health loss and poor quality of life (QoL)1. Globally, approximately 1-8% of the population suffers from PsO2, 3. Among PsO patients, the prevalence of psoriatic arthritis (PsA) is estimated to be between 6% and 41%3.

EGFR-Mutation-Positive NSCLC: Choosing the Best Therapeutic Strategy

By: Nick Turner, PhD, Senior Director Activating mutations in the EGFR gene are found in about 10-12% of all non-small cell lung cancer (NSCLC) cases and around 50% of cases in East-Asian patients. Cancer in patients with mutations is driven by constitutive activation of EGFR-signaling pathways due to acquired mutations in the catalytic domain of the receptor rendering them amenable to EGFR-tyrosine kinase inhibition1.

Checkpoint Inhibitors: Changing the Treatment Paradigm in Metastatic NSCLC

By: Nick Turner, PhD, Senior DirectorLung cancer is the leading cause of cancer mortality worldwide, accounting for more than 1.6 million deaths annually. Non-small cell lung cancer (NSCLC) accounts for 85% of all new cases. Current first-line treatment decisions for metastatic NSCLC mandate analysis of the genetic status of the cancer to determine the presence of driver mutations, such as activating mutations in the epidermal growth factor receptor (EGFR) or anaplastic lymphoma kinase (ALK). In mutation-positive patients, first-line treatment comprises small molecule inhibitors of EGFR-tyrosine kinase, e.g., gefitinib, afatinib or osimertinib, or ALK inhibitors, e.g., alectinib or crizotinib. Roughly 85% of patients with NSCLC, however, do not harbor these oncogenic drivers; in these patients, treatment options have been limited to platinum-based chemotherapy. The emergence of immune checkpoint inhibitors, which attenuate immunosuppression within the tumor microenvironment and enable the immune system to attack tumor cells, opens the door to more effective therapy with durable responses and manageable toxicity.

New Paradigms in the Treatment of Breast Cancer

By: Nick Turner, PhD and Paula Palacios Fernandez, MScBreast cancer is the most common cancer in women with more than 2.1 million new cases diagnosed in 2018. And with more than 600,000 deaths in 2018, it is the second-leading cause of cancer deaths in women worldwide (WHO). Advances have been made across all stages and sub-types of the disease and provide hope for improved treatment options, lower rates of relapse and better survival outcomes. The development of agents against novel molecular targets, including inhibitors of PARP, CDK4/6, PI3K and immune checkpoints, offers treatment options for patients with previously poor prognoses and treatment-resistant disease. We describe some recent  developments below.

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