How Pembrolizumab Became Oncology’s Closest Thing to a “Silver Bullet”
Are genius molecules a product of nature or nurture?
How you spend your CI budget is as important as how much you are spending; therefore, it is vital to assess the upfront value associated with each potential project in order to ensure your money goes where it should and that the management team is happy.
Kevin Baruzzi, Dr. Arun R. Shrivats and Daria Andreeva
Among the available cancer treatments, pembrolizumab is an industry bellwether: A drug that is as close to a “silver bullet” as the industry has ever had in history. Here are some of the facts about pembrolizumab that have given it a hero status among oncology patients worldwide:
Pembrolizumab has opened up new paradigms in oncology treatment, including a shift toward a molecule-based paradigm (TMB, MSI-H) from a tumor biology-based paradigm. It has also successfully led the charge on a precision, biomarker-based approach to immunotherapy, which has been the province of targeted therapies until now.
Projections suggest pembrolizumab is clearly still an ascendant product: Its sales in 2019 were $12 billion, with analysts estimating this figure will reach $22 billion by 2025.
When a game-changing drug such as pembrolizumab appears on the horizon, one must be intellectually curious and ask how it came into being.
Was pembrolizumab a special molecule – a find of nature – that heralded, perhaps via the minutest alteration, an immunotherapy breakthrough, a chemistry miracle?
Or was pembrolizumab a talent that fell into the right hands and was housed in labs where scientists knew exactly how to nurture it?
To layman eyes viewing the image below, the temptation may be to see the remarkable similarity between pembrolizumab nivolumab (BMS’ compound) and say “nature”.
Like all genius successes, this brings us to a critical ingredient: The way pembrolizumab has been nurtured, and the credit here goes to Merck, perhaps even more so to Merck Research Labs (MRL). MRL-led studies have defied industry expectations on probabilistic success and failure.
Are there learnings here for pharmaceutical companies in general? The answer is a resounding yes.