Prescient’s Anna Graca has published an article in GLIA:
RNAi-mediated suppression of vimentin
Glial scar is considered to be a major factor limiting endogenous regeneration throughout the central nervous system. Novel study showed that RNAi-mediated suppression of intermediate filament proteins (IFs), vimentin and glial fibrillary acidic protein, prevents the establishment of glial scar in progressive retinal degeneration. These data further deepen our understanding of the roles played by different IFs in the complex process of gliosis, and open new therapeutic avenues for potentially ameliorating this aspect of glial scarring in retinal and CNS degeneration.